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KMID : 0350519960490010397
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Journal of Catholic Medical College
1996 Volume.49 No. 1 p.397 ~ p.406
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Alterations of Plasma Prostaglandin E2 and Serum Lipid Levels in Kawasaki Disease
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Abstract
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Kawasaki disease (KD) is an acute febrile illness associated with marked increase of multiple cytokines which are responsible for the development of systemic vasculitis in this disease. Some cytokines including tumor necrosis factor increase
lipolysis
of fat tissue, resulting in increase of circulating free fatty acid (FFA) levels, which stimulated hepatic triglyceride production, thererby contribute to hyperlipidemia. Recently some reports suggest that cytokine induced lipolysis is mediated
by
local
prostaglandin synthesis. In order to evaluate the alterations of prostagandin and lipid metabolism in Kawasaki disease, we measured the plasma levels of PGE2 and serum levels of FFA, triglyceride (TG), total cholesterol (TC), high-density
lipoprotein
cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) patients with acute (N=18) and convalescent (n=20) stages of KD, other febrile patients due to acute infection (n=15), and normal children (n=15). Among KD patients, 15 were as
follows as
follows:
@ES The results were as follows:
@EN 1. Plasma PGF2 levels of the acute stage KD patients were significantly elevated as compared with those of the convalescent stage KD patients or the normal control group. Plasma PGE2 levels of the patients with acute infection weer somewhat
higher
but not significantly different from those of the normal control group.
2. Serum FFA levels of the acute stage KD patients were significantly elevated as compared with those of the convalescent stage KD patients or the normal control group. serum FFA levels of the patients with acute infection were also elevated but
not
significantly different from those of the normal control group.
3. TG and TC levels were significantly higer in the convalescent stage KD patients than those in the acute stage KD patients or the normal control group. HDL-C levels of the acute stage KD patients were significantly lower than those of the
normal
group. LDL-C levels showed no sinificant differences between the groups.
In conclusion, serum FFA levels which mean the degree of lipolysis were significantly increased at the acute stage of KD but returned to normal range at the convalescent stage of KD< when hypertriglyceridemia and hypercholesterolemia developed.
Similar
changes were observed in acute infection but not significant. Plasma PGE2 levels were also elevated at the acute stage of KD and returned to normal range at the convalescent stage of KD, suggesting that PGE2 may play an role in inflammatory and
lipolytic reaction at the acute stage of KD.
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KEYWORD
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